Samuel Eto'o scored a scintillating home hat-trick for holders Inter Milan in the Champions League on Wednesday as former Barcelona teammate Lionel Messi's magic went missing in a 1-1 draw in Russia.
Inter Milan produced a rip-roaring home performance to overpower Barcelona 3-1 and leave the holders in real trouble after an awe-inspiring Champions League first-leg semi-final on Tuesday.
The draw was made on Monday for the Champions League round of 16.
Barcelona and AC Milan qualified for the last 16 of the Champions League as expected with room to spare on Tuesday and surprise package APOEL Nicosia are poised to join them after continuing to punch above their weight.
In a big blow to Real Madrid's title hopes, Real Betis held them to a goalless draw in their La Liga encounter on Sunday.
Atletico Madrid coach Diego Simeone praised his team's spirit after knocking holders Barcelona out of the Champions League.
Group C leaders Barcelona should make it four wins from four matches against pointless Basel on Tuesday in the Champions League, while holders Manchester United can book their last 16 place with victory at Celtic.
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
King's Cup holders Barcelona have a fight on their hands if they are to remain in the competition after losing a fiery first leg of their last-16 tie at Athletic Club 2-1 on Thursday despite playing the final 10 minutes with a two-man advantage. Spain striker Aritz Aduriz headed Bilbao in front in the 25th minute and the veteran produced an audacious flick to tee up youngster Inaki Williams to volley in the second three minutes later. Talisman Lionel Messi pulled a full-strength Barca side back into the game with a free-kick in the 52nd minute which came off the underside of the bar and over the line.
Images from the Champions League matches played across Europe on Tuesday.
Holders FC Barcelona have been placed in Group E, along with Bayer Leverkusen, AS Roma, Dinamo Zagreb.
A spot of Andres Iniesta magic and a late David Villa strike lifted profligate Barcelona to a 2-0 home win over competition newcomers Viktoria Plzen in Champions League Group H on Wednesday.
Lionel Messi and Luis Suarez were on target as holders Barcelona thrashed Real Sociedad 5-2 to reach the King's Cup semi-finals for the seventh successive year with a 6-2 aggregate victory on Thursday.
Levante claim that Barcelona's teenage defender Chumi Brandariz, who played in the first leg, was ineligible to take part in the match because he was suspended.
With a fifth world player of the year award safely tucked away in the trophy cabinet, Lionel Messi can set his sights on one of the next milestones in his remarkable career: reaching 500 goals for club and country. The Barcelona and Argentina forward can add to his jaw-dropping tally of 479 in 609 official games -- 430 for Barca and 49 for his national team -- in Sunday's La Liga match at home to Athletic Bilbao. The 28-year-old from Rosario, who picked up the FIFA Ballon d'Or on Monday, is looking close to his best following a two-month injury layoff late last year and netted a hat-trick when second-placed Barca crushed Granada 4-0 at the Nou Camp last weekend in their most recent outing in Spain's top flight.
Holders Barcelona were knocked out of the King's Cup on Wednesday when they won a thrilling last-16 second-leg clash at Sevilla 1-0 but were eliminated on the away goals rule after the tie ended 2-2 on aggregate.
Arsenal's defence not afraid of Barcelona trio, says Ozil
Barcelona dealt a stinging blow to Real Madrid's title hopes when Luis Suarez and Neymar continued their scintillating form to fire the champions to a stunning 4-0 victory in the La Liga 'Clasico' on Saturday.
Federico Valverde finished off a stunning move in extra time to give Real Madrid a 3-2 victory over arch-rivals Barcelona
Philippe Coutinho scored his first league goal since returning to Barcelona to help his side draw 1-1 at home to an excellent Sevilla side in La Liga on Sunday.
Chelsea have parted company with manager Roberto Di Matteo just six months after the Italian led the London club to a first Champions League title.
Paris St Germain had a chance to extend their Ligue 1 lead to five points after RC Lens drew 1-1 at Troyes and Olympique de Marseille and Monaco shared the spoils on Saturday.
Here is what you need to know about their route to the final
Barcelona coach Pep Guardiola is in danger of tarnishing his reputation as the man with the Midas touch when the holders seek to overturn a 1-0 deficit against Chelsea in Tuesday's Champions League semi-final second leg at the Nou Camp.
Brazil striker Neymar scored a sublime opening goal as he inspired Santos to an exciting 3-1 victory over Japan's Kashiwa Reysol in a Club World Cup semi-final in Toyota on Wednesday.
Barcelona coach Pep Guardiola has played down this weekend's 'clasico' match at Real Madrid by saying a European Union summit meeting on Friday and moves to save the Euro were much more significant.
Didier Drogba scored late in the first half and Chelsea kept free-scoring Lionel Messi in check to secure a 1-0 win over holders Barcelona in their Champions League semi-final first leg on Wednesday.
Holders Barcelona and Bayern Munich reached the Champions League semi-finals with home wins over AC Milan and Olympique Marseille respectively on Tuesday as Lionel Messi broke another record with his 13th and 14th goals of this season's competition.
Not even 100 metres world record holder Usain Bolt could have caught AC Milan's Alexandre Pato when he streaked through to score against Barcelona after 24 seconds on Tuesday, Barca coach Pep Guardiola said.
Barcelona set up a King's Cup final against Athletic Bilbao when Cesc Fabregas scored one goal and created another for Xavi in a 2-0 win over 10-man Valencia in their semi-final second leg on Wednesday.
Andres Iniesta celebrated being named on the shortlist for the FIFA World Player of the Year award with a glorious goal for Barcelona as the holders won 3-0 at Alaves in a King's Cup last-32 first leg on Tuesday.
Real Madrid are set be thrown out of the Spanish King's Cup after playing banned Russian winger Denis Cheryshev in their last-32 win over Cadiz on Wednesday.
Barcelona dealt Real Madrid another body blow when they survived a stirring fightback from their arch rivals to draw 2-2 in an action-packed King's Cup quarter-final second leg on Wednesday and send the holders out 4-3 on aggregate.
A second-string Barcelona set up a King's Cup quarter-final clash against holders and great rivals Real Madrid when they came back from a goal down to beat Osasuna 2-1 on Thursday for a 6-1 aggregate victory.
Images from the Champions League second-leg match played on Wednesday.
Cristiano Ronaldo struck a late goal to help Real Madrid beat third tier Ponferradina 2-0 away in a King's Cup last-32, first-leg match, on Tuesday, as the holders looked to recover from their demoralising 'El Clasico' defeat by Barcelona at the weekend.
Lionel Messi is 34 goals short of becoming Barcelona's all-time top scorer after netting a hat-trick in the Champions League on Tuesday, and the only real question left is when he will achieve that accolade and not if.
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Barcelona crashed out of the Champions League following a 3-0 defeat at Bayern Munich on Wednesday, failing to make it past the group stage of the competition for the first time since the 2000-01 season.